Side Effects & What to Expect During Treatment

Good Girl Rx providers focus exclusively on prescribing and managing your primary treatment plan. We do not prescribe anti-nausea medication, acid reflux medication, anti-diarrheal medication, or any other supportive or remedy-type medications.

If you experience side effects that require additional medication, please contact your primary care physician or visit an urgent care clinic. They can prescribe supportive medications such as ondansetron (Zofran) for nausea, famotidine (Pepcid) for acid reflux, or loperamide (Imodium) for diarrhea.

If you experience a medical emergency, call 911 immediately.

Nausea is the most commonly reported side effect, especially during the first few weeks or after a dose increase. It typically improves as your body adjusts. To help manage nausea: eat smaller, more frequent meals throughout the day; avoid greasy, fried, or heavy foods; eat slowly and stop when you feel full; stay well hydrated with water and clear fluids; avoid lying down immediately after eating. If nausea is severe or persistent, contact your provider through the patient portal — they may recommend adjusting your dose.

Constipation affects many patients as GLP-1 medications slow gastric emptying. To help: increase your fiber intake gradually, drink plenty of water throughout the day, stay physically active, and consider an over-the-counter stool softener like docusate sodium (Colace). If constipation is severe or lasts more than a week, message your provider.

Diarrhea may occur, particularly in the early weeks of treatment. Stay hydrated with water and electrolyte drinks. Avoid high-fat and spicy foods. Over-the-counter remedies like loperamide (Imodium) may help — consult your primary care physician if diarrhea persists.

Injection site reactions such as redness, swelling, itching, or mild pain at the injection site are common and usually resolve on their own within a few days. Rotate your injection sites between your abdomen, thigh, and upper arm to minimize irritation.

Headaches may occur during the first few weeks as your body adjusts. Stay hydrated, get adequate rest, and use over-the-counter pain relief like acetaminophen (Tylenol) if needed.

Fatigue and dizziness can happen as your body adjusts to lower caloric intake and changes in blood sugar levels. Make sure you are eating enough nutritious food, staying hydrated, and getting adequate sleep.

Acid reflux and heartburn can occur because GLP-1 medications slow digestion. Eat smaller meals, avoid eating close to bedtime, avoid spicy and acidic foods, and elevate your head while sleeping. Over-the-counter antacids like Tums or famotidine (Pepcid) can help — contact your primary care doctor if symptoms persist.

Decreased appetite is an expected effect of the medication and is part of how GLP-1s support weight loss. However, it is important to continue eating regular, balanced meals to ensure proper nutrition.

Stomach pain or bloating may occur occasionally. Eating smaller portions and avoiding carbonated beverages may help.

Gas and burping are related to changes in digestion speed. Eating slowly and avoiding gas-producing foods can reduce these symptoms.

Hair thinning has been reported by some patients during rapid weight loss. This is generally related to the weight loss itself, not the medication directly, and is usually temporary. Ensure you are getting adequate protein and nutrition.

Message your Good Girl Rx provider through the patient portal at https://my.goodgirlrx.com if you experience: side effects that are not improving after 2–3 weeks; side effects that are interfering with your daily life; vomiting that prevents you from keeping food or liquids down for more than 24 hours; or if you want to discuss a dose adjustment.

Call 911 or go to your nearest emergency room if you experience: severe abdominal pain that does not go away; signs of an allergic reaction such as difficulty breathing, swelling of the face, lips, tongue, or throat, or severe rash; signs of pancreatitis such as severe pain in the upper stomach that radiates to the back, with nausea and vomiting; symptoms of gallbladder problems such as pain in the upper right abdomen, fever, and yellowing of the skin or eyes; signs of kidney problems such as changes in urination, swelling in legs or ankles; or thoughts of self-harm or suicide (rare, but seek help immediately).

Side effects often return temporarily when your dose is increased. This is normal. Your body typically adjusts within 1–2 weeks. Follow the same management tips above. If side effects are severe after a dose increase, contact your provider — they may recommend stepping back to your previous dose before trying again.

Injection site reactions such as redness, swelling, or mild soreness at the injection site are the most common side effect. These are typically mild and resolve within a day or two. Rotate injection sites to reduce irritation.

Nausea may occur, especially at higher doses or when increasing too quickly. If you experience nausea, your provider may recommend slowing your dose escalation.

Headaches can occur during the initial weeks of treatment and usually improve as your body adjusts.

Flushing or warmth — some patients report a feeling of warmth or flushing shortly after injection. This is generally mild and temporary.

Fatigue — while NAD+ is intended to boost energy, some patients initially experience fatigue as their body adjusts. This typically resolves within the first week or two.

Lightheadedness may occur in some patients. Stay hydrated and sit or lie down if you feel dizzy after your injection.

Message your provider through the patient portal if you experience: side effects that persist beyond 2 weeks; nausea or discomfort when increasing your dose; any symptoms that concern you or interfere with your daily routine.

Call 911 or go to your nearest emergency room if you experience: signs of a severe allergic reaction such as difficulty breathing, chest tightness, or severe swelling; chest pain or heart palpitations; or any symptoms you believe require immediate medical attention.

Injection site reactions including redness, swelling, pain, or itching at the injection site are common and usually mild.

Headaches may occur during the early weeks of treatment.

Flushing and warmth can happen shortly after injection.

Dizziness or lightheadedness may occur. Inject your dose before bedtime if this is an issue, as sermorelin is often recommended to be taken at night.

Difficulty swallowing or changes in taste have been reported rarely.

Message your provider through the patient portal if side effects do not improve within the first few weeks or if you have concerns about your treatment.

Injection site reactions such as redness, itching, rash, swelling, or pain are the most common side effects.

Joint pain or stiffness may occur in some patients.

Swelling in hands or feet can happen due to fluid retention.

Numbness or tingling in hands or feet has been reported by some patients.

Headaches and nausea may occur during the early weeks of treatment.

Message your provider if you experience persistent joint pain, significant swelling, or numbness and tingling that does not resolve.

Injection site reactions such as mild pain, redness, or swelling are the most common side effect and are usually mild.

Bloating or stomach cramps may occur in some patients.

Allergic reactions are rare but possible. If you experience any signs of an allergic reaction, seek medical attention.

Glutathione injections are generally very well tolerated with minimal side effects.

Injection site reactions including mild pain, redness, or swelling at the injection site.

Mild diarrhea may occur in some patients.

Headache or dizziness can happen but is usually temporary.

Nausea is uncommon but may occur.

B12 injections are generally very well tolerated.

Injection site reactions such as pain, redness, or swelling are the most common side effect.

Upset stomach or diarrhea may occur.

Fatigue can happen in some patients during the first week.

Headaches may occur but are typically mild.

Blue-green discoloration of urine is expected and completely normal. This is not harmful.

Blue staining of the mouth, tongue, or skin may occur temporarily.

Nausea or stomach discomfort can happen in some patients.

Headaches may occur.

Dizziness has been reported by some patients.

Methylene blue can interact with certain medications, particularly serotonergic drugs such as SSRIs, SNRIs, and MAOIs. If you are taking any antidepressants or psychiatric medications, make sure your provider is aware, as there is a risk of serotonin syndrome, which is a serious condition.

Seek immediate medical attention if you experience: confusion, agitation, rapid heart rate, high blood pressure, dilated pupils, muscle twitching, or high fever — these may be signs of serotonin syndrome. Also seek emergency care for difficulty breathing or signs of a severe allergic reaction.

Stay hydrated by drinking at least 8 glasses of water per day. Eat balanced, nutritious meals even if your appetite is reduced. Follow your prescribed dosing instructions exactly — do not adjust your dose on your own. Keep all medications refrigerated per the storage instructions provided with your shipment. Rotate injection sites to minimize irritation. Take your injections at the same time each day for consistency. Track your side effects and report them to your provider through the patient portal.

Log in to your patient portal at https://my.goodgirlrx.com, click "Chat" on the left menu (desktop) or bottom menu (mobile), and click "Doctor" to message your provider directly. Providers typically respond within 24–48 hours.

For non-medical questions about orders, shipping, billing, or account access, reach out through our help center at https://help.goodgirlrx.com or message us through the chat widget on our website. We do not offer phone support.

This information is for educational purposes only and is not a substitute for professional medical advice. Always consult your healthcare provider about any side effects or concerns. If you are experiencing a medical emergency, call 911.